Martin L. Chalfie

2008 Nobel Laureate in Chemistry

Martin Lee Chalfie is an American scientist. He is University Professor at Columbia University and member of the American National Academy of Sciences. He shared the 2008 Nobel Prize in Chemistry along with Osamu Shimomura and Roger Y. Tsien "for the discovery and development of the green fluorescent protein, GFP".


Chalfie's lab uses the nematode C. elegans to investigate aspects of nerve cell development and function. The wealth of developmental, anatomical, genetic, and molecular information available for C. elegans provides a powerful and multifaceted approach to these studies.


He has published over 100 papers of which at least 25 have over 100 citations.


He traces his work on Green fluorescent protein to a 1988 seminar from Paul Brehm about bioluminescent organisms, which led to some crucial experiments in 1992, detailed in his paper “Green fluorescent protein as a marker for gene expression”, which is among the 20 most-cited papers in the field of Molecular Biology & Genetics. Chalfie won a Golden Goose Award for this work in 2012.

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